Publications

* denotes equal contribution. Underlined names indicate current and former staff of our institute.
List updated on 5th March 2018.

2018

Gross JC, Zelarayan LC. The Mingle-Mangle of Wnt Signaling and Extracellular Vesicles: Functional Implications for Heart Research. Front Cardiovasc Med. 2018 Feb; 5:10. doi: 10.3389/fcvm.2018.00010.

Molina CE, Jacquet E, Ponien P, Muñoz-Guijosa C, Baczkó I, Maier LS, Donzeau-Gouge P, Dobrev D, Fischmeister R, Garnier A. Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart. Cardiovasc Res. 2018 Feb 1;114(2):247-258. doi: 10.1093/cvr/cvx182. PubMed PMID: 29036603.

El-Battrawy I, Zhao Z, Lan H, Schünemann JD, Sattler K, Buljubasic F, Patocskai B, Li X, Yücel G, Lang S, Nowak D, Cyganek L, Bieback K, Utikal J, Zimmermann WH, Ravens U, Wieland T, Borggrefe M, Zhou XB, Akin I. Estradiol protection against toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes. Int J Cardiol. 2018 Mar 1;254:195-202. doi: 10.1016/j.ijcard.2017.11.007. Epub 2018 Jan 28. PubMed PMID: 29407091.

Long C, Li H, Tiburcy M, Rodriguez-Caycedo C, Kyrychenko V, Zhou H, Zhang Y, Min YL, Shelton JM, Mammen PPA, Liaw NY, Zimmermann WH, Bassel-Duby R, Schneider JW, Olson EN. Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing. Sci Adv. 2018 Jan 31;4(1):eaap9004. doi: 10.1126/sciadv.aap9004. eCollection 2018 Jan. PubMed PMID: 29404407.

Iyer LM, Nagarajan S, Woelfer M, Schoger E, Khadjeh S, Zafiriou MP, Kari V, Herting J, Pang ST, Weber T, Rathjens FS, Fischer TH, Toischer K, Hasenfuss G, Noack C, Johnsen SA, Zelarayán LC. A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart. Nucleic Acids Res. 2018 Jan 31. doi: 10.1093/nar/gky049. [Epub ahead of print] PubMed PMID: 29394407.

Zhao X, Chen H, Xiao D, Yang H, Itzhaki I, Qin X, Chour T, Aguirre A, Lehmann K, Kim Y, Shukla P, Holmström A, Zhang JZ, Zhuge Y, Ndoye BC, Zhao M, Neofytou E, Zimmermann WH, Jain M, Wu JC. Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. Stem Cell Reports. 2018 Jan 26. pii: S2213-6711(18)30028-6. doi: 10.1016/j.stemcr.2018.01.002. [Epub ahead of print] PubMed PMID: 29398480.

Heijman J, Kirchner D, Kunze F, Chrétien EM, Michel-Reher MB, Voigt N, Knaut M, Michel MC, Ravens U, Dobrev D. Muscarinic type-1 receptors contribute to I(K,ACh) in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation. Int J Cardiol. 2018 Mar 15;255:61-68. doi: 10.1016/j.ijcard.2017.12.050. Epub 2017 Dec 22. PubMed PMID: 29290419.

Meyer T, Voigt N. In search for novel functions of adenosine 5'-triphosphate (ATP) in the heart. Cardiovasc Res. 2017 Dec 1;113(14):e59-e60. doi: 10.1093/cvr/cvx207. PubMed PMID: 29186438.

Voigt N, Mason F, Thomas D. Report on the Ion Channel Symposium: Organized by the German Cardiac Society Working Group on Cellular Electrophysiology (AG 18). Herzschrittmacherther Elektrophysiol. 2018 Jan 8. doi: 10.1007/s00399-017-0549-4. [Epub ahead of print] Review. PubMed PMID: 29313139.

Voigt N, Lederer WJ. Niels Voigt talks to W. Jonathan Lederer, keynote lecturer at the "Göttingen Channels" Symposium 2017. Cardiovasc Res. 2018 Feb 1;114(2):e14. doi: 10.1093/cvr/cvx241. PubMed PMID: 29373724.

Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, Ingelman-Sundberg M, Jang KJ, Jones DR, Lauschke VM, Marx U, Mettetal JT, Pointon A, Williams D, Zimmermann WH, Newham P. Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:65-82. doi: 10.1146/annurev-pharmtox-010617-052722. Epub 2017 Oct 13. PubMed PMID: 29029591.

Khan FM, Saleh E, Alawadhi H, Harati R, Zimmermann WH, El-Awady R. Inhibition of exosome release by ketotifen enhances sensitivity of cancer cells to doxorubicin. Cancer Biol Ther. 2018 Jan 2;19(1):25-33. doi:10.1080/15384047.2017.1394544. Epub 2017 Dec 15. PubMed PMID: 29244610.


2017

Schmidt C, Wiedmann F, Zhou XB, Heijman J, Voigt N, Ratte A, Lang S, Kallenberger SM, Campana C, Weymann A, De Simone R, Szabo G, Ruhparwar A, Kallenbach K, Karck M, Ehrlich JR, Baczkó I, Borggrefe M, Ravens U, Dobrev D, Katus HA, Thomas D. Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy. Eur Heart J. 2017 Jun 7;38(22):1764-1774. doi: 10.1093/eurheartj/ehw559. PubMed PMID: 28057773.

Meyer T, Voigt N. In search for novel functions of adenosine 5'-triphosphate (ATP) in the heart. Cardiovasc Res. 2017 Dec 1;113(14):e59-e60. doi: 10.1093/cvr/cvx207. PubMed PMID: 29186438.

Molina CE, Voigt N. Finding Ms or Mr Right: Which miRNA to target in AF? J Mol Cell Cardiol. 2017 Jan;102:22-25. doi: 10.1016/j.yjmcc.2016.11.007. Epub 2016 Nov 17. PubMed PMID: 27866930.

Ji Y, Varkevisser R, Opacic D, Bossu A, Kuiper M, Beekman JDM, Yang S, Khan AP, Dobrev D, Voigt N, Wang MZ, Verheule S, Vos MA, van der Heyden MAG. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 Aug;174(15):2576-2590. doi: 10.1111/bph.13869. Epub 2017 Jun 28. PubMed PMID: 28542844.

Schmidt C, Wiedmann F, Kallenberger SM, Ratte A, Schulte JS, Scholz B, Müller FU, Voigt N, Zafeiriou MP, Ehrlich JR, Tochtermann U, Veres G, Ruhparwar A, Karck M, Katus HA, Thomas D. Stretch-activated two-pore-domain (K(2P)) potassium channels in the heart: Focus on atrial fibrillation and heart failure. Prog Biophys Mol Biol. 2017 Nov;130(Pt B):233-243. doi: 10.1016/j.pbiomolbio.2017.05.004. Epub 2017 May 16. PubMed PMID: 28526353.

Linke F, Harenberg M, Nietert MM, Zaunig S, von Bonin F, Arlt A, Szczepanowski M, Weich HA, Lutz S, Dullin C, Janovská P, Krafčíková M, Trantírek L, Ovesná P, Klapper W, Beissbarth T, Alves F, Bryja V, Trümper L, Wilting J, Kube D. Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia. 2017 Feb;31(2):361-372. doi: 10.1038/leu.2016.232. Epub 2016 Aug 18. PubMed PMID: 27535218.

Linke F, Zaunig S, Nietert MM, von Bonin F, Lutz S, Dullin C, Janovská P, Beissbarth T, Alves F, Klapper W, Bryja V, Pukrop T, Trümper L, Wilting J, Kube D. WNT5A: a motility-promoting factor in Hodgkin lymphoma. Oncogene. 2017 Jan 5;36(1):13-23. doi: 10.1038/onc.2016.183. Epub 2016 Jun 6. PubMed PMID: 27270428 .

Wottawa M, Naas S, Böttger J, van Belle GJ, Möbius W, Revelo NH, Heidenreich D, von Ahlen M, Zieseniss A, Kröhnert K, Lutz S, Lenz C, Urlaub H, Rizzoli SO, Katschinski DM. Hypoxia-stimulated membrane trafficking requires T-plastin. Acta Physiol (Oxf). 2017 Sep;221(1):59-73. doi: 10.1111/apha.12859. Epub 2017 Mar 23. PubMed PMID: 28218996.

Castillo-Gómez E, Oliveira B, Tapken D, Bertrand S, Klein-Schmidt C, Pan H, Zafeiriou P, Steiner J, Jurek B, Trippe R, Prüss H, Zimmermann WH, Bertrand D, Ehrenreich H, Hollmann M. All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class. Mol Psychiatry. 2017 Dec;22(12):1776-1784. doi: 10.1038/mp.2016.125. Epub 2016 Aug 9. PubMed PMID: 27502473.

Gröschel C, Sasse A, Röhrborn C, Monecke S, Didié M, Elsner L, Kruse V, Bunt G, Lichtman AH, Toischer K, Zimmermann WH, Hasenfuß G, Dressel R. T helper cells with specificity for an antigen in cardiomyocytes promote pressure overload-induced progression from hypertrophy to heart failure. Sci Rep. 2017 Nov 22;7(1):15998. doi: 10.1038/s41598-017-16147-1. PubMed PMID: 29167489.

Abilez OJ, Tzatzalos E, Yang H, Zhao MT, Jung G, Zöllner AM, Tiburcy M, Riegler J, Matsa E, Shukla P, Zhuge Y, Chour T, Chen VC, Burridge PW, Karakikes I, Kuhl E, Bernstein D, Couture LA, Gold JD, Zimmermann WH, Wu JC. Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling. Stem Cells. 2018 Feb;36(2):265-277. doi: 10.1002/stem.2732. Epub 2017 Nov 13. PubMed PMID: 29086457.

Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, Ingelman-Sundberg M, Jang KJ, Jones DR, Lauschke VM, Marx U, Mettetal JT, Pointon A, Williams D, Zimmermann WH, Newham P. Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:65-82. doi: 10.1146/annurev-pharmtox-010617-052722. Epub 2017 Oct 13. PubMed PMID: 29029591.

Streckfuss-Bömeke K, Tiburcy M, Fomin A, Luo X, Li W, Fischer C, Özcelik C, Perrot A, Sossalla S, Haas J, Vidal RO, Rebs S, Khadjeh S, Meder B, Bonn S, Linke WA, Zimmermann WH, Hasenfuss G, Guan K. Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2017 Dec;113:9-21. doi: 10.1016/j.yjmcc.2017.09.008. Epub 2017 Sep 21. PubMed PMID: 28941705.

Kyrychenko V, Kyrychenko S, Tiburcy M, Shelton JM, Long C, Schneider JW, Zimmermann WH, Bassel-Duby R, Olson EN. Functional correction of dystrophin actin binding domain mutations by genome editing. JCI Insight. 2017 Sep 21;2(18). pii: 95918. doi: 10.1172/jci.insight.95918. [Epub ahead of print] PubMed PMID: 28931764.

Noack C, Haupt LP, Zimmermann WH, Streckfuss-Bömeke K, Zelarayán LC. Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation. Stem Cell Res. 2017 Aug;23:127-131. doi: 10.1016/j.scr.2017.07.007. Epub 2017 Jul 11. PubMed PMID: 28925362.

Koopman CD, Zimmermann WH, Knöpfel T, de Boer TP. Cardiac optogenetics: using light to monitor cardiac physiology. Basic Res Cardiol. 2017 Aug 31;112(5):56. doi: 10.1007/s00395-017-0645-y. Review. PubMed PMID: 28861604.

Didié M, Galla S, Muppala V, Dressel R, Zimmermann WH. Immunological Properties of Murine Parthenogenetic Stem Cell-Derived Cardiomyocytes and Engineered Heart Muscle. Front Immunol. 2017 Aug 14;8:955. doi: 10.3389/fimmu.2017.00955. eCollection 2017. PubMed PMID: 28855904.

Johannsen H, Muppala V, Gröschel C, Monecke S, Elsner L, Didié M, Zimmermann WH, Dressel R. Immunological Properties of Murine Parthenogenetic Stem Cells and Their Differentiation Products. Front Immunol. 2017 Aug 4;8:924. doi: 10.3389/fimmu.2017.00924. eCollection 2017. PubMed PMID: 28824647.

Borchert T, Hübscher D, Guessoum CI, Lam TD, Ghadri JR, Schellinger IN, Tiburcy M, Liaw NY, Li Y, Haas J, Sossalla S, Huber MA, Cyganek L, Jacobshagen C, Dressel R, Raaz U, Nikolaev VO, Guan K, Thiele H, Meder B, Wollnik B, Zimmermann WH, Lüscher TF, Hasenfuss G, Templin C, Streckfuss-Bömeke K. Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy. J Am Coll Cardiol. 2017 Aug 22;70(8):975-991. doi: 10.1016/j.jacc.2017.06.061. PubMed PMID: 28818208.

Fujita B, Zimmermann WH. Myocardial Tissue Engineering for Regenerative Applications. Curr Cardiol Rep. 2017 Sep;19(9):78. doi: 10.1007/s11886-017-0892-4. Review. PubMed PMID: 28752277.

Fujita B, Zimmermann WH. Engineered Heart Repair. Clin Pharmacol Ther. 2017 Aug;102(2):197-199. doi: 10.1002/cpt.724. Epub 2017 Jun 29. Review. PubMed PMID: 28661033.

Yücel G, Zhao Z, El-Battrawy I, Lan H, Lang S, Li X, Buljubasic F, Zimmermann WH, Cyganek L, Utikal J, Ravens U, Wieland T, Borggrefe M, Zhou XB, Akin I. Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes. Sci Rep. 2017 Jun 7;7(1):2935. doi: 10.1038/s41598-017-03147-4. PubMed PMID: 28592841.

Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A. Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure. Circ Heart Fail. 2017 May;10(5):e003840. doi: 10.1161/CIRCHEARTFAILURE.117.003840. PubMed PMID: 28487342.

Zimmermann WH. Remuscularization of the failing heart. J Physiol. 2017 Jun 15;595(12):3685-3690. doi: 10.1113/JP273098. Epub 2017 Apr 25. PubMed PMID: 28295371.

Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake LW, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH. Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair. Circulation. 2017 May 9;135(19):1832-1847. doi: 10.1161/CIRCULATIONAHA.116.024145. Epub 2017 Feb 6. PubMed PMID: 28167635.

Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation. 2017 Feb 28;135(9):881-897. doi: 10.1161/CIRCULATIONAHA.116.022852. Epub 2016 Dec 7. PubMed PMID: 27927712.

Zimmermann WH. Translating Myocardial Remuscularization. Circ Res. 2017 Jan 20;120(2):278-281. doi: 10.1161/CIRCRESAHA.116.310194. PubMed PMID: 28104769.


2016

Qin X, Riegler J, Tiburcy M, Zhao X, Chour T, Ndoye B, Nguyen M, Adams J, Ameen M, Denney TS Jr, Yang PC, Nguyen P, Zimmermann WH, Wu JC. Magnetic Resonance Imaging of Cardiac Strain Pattern Following Transplantation of Human Tissue Engineered Heart Muscles. Circ Cardiovasc Imaging. 2016 Nov;9(11). pii: e004731. PubMed PMID: 27903535.

El-Battrawy I, Lang S, Zhao Z, Akin I, Yücel G, Meister S, Patocskai B, Behnes M, Rudic B, Tülümen E, Liebe V, Tiburcy M, Dworacek J, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou XB. Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. PLoS One. 2016 Nov 9;11(11):e0166143. doi: 10.1371/journal.pone.0166143. eCollection 2016. PubMed PMID: 27829006.

Ogle BM, Bursac N, Domian I, Huang NF, Menasché P, Murry CE, Pruitt B, Radisic M, Wu JC, Wu SM, Zhang J, Zimmermann WH, Vunjak-Novakovic G. Distilling complexity to advance cardiac tissue engineering. Sci Transl Med. 2016 Jun 8;8(342):342ps13. doi: 10.1126/scitranslmed.aad2304. Review. PubMed PMID: 27280684.

Zeidler S, Meckbach C, Tacke R, Raad FS, Roa A, Uchida S, Zimmermann WH, Wingender E, Gültas M. Computational Detection of Stage-Specific Transcription Factor Clusters during Heart Development. Front Genet. 2016 Mar 23;7:33. doi: 10.3389/fgene.2016.00033. eCollection 2016. PubMed PMID: 27047536.

Zimmermann WH. Strip and Dress the Human Heart. Circ Res. 2016 Jan 8;118(1):12-3. doi: 10.1161/CIRCRESAHA.115.307938. Erratum in: Circ Res. 2016 Mar 18;118(6):e33. PubMed PMID: 26837739.

Liaw NY, Zimmermann WH. Mechanical stimulation in the engineering of heart muscle. Adv Drug Deliv Rev. 2016 Jan 15;96:156-60. doi: 10.1016/j.addr.2015.09.001. Epub 2015 Sep 8. Review. PubMed PMID: 26362920.


2015

Zimmermann WH. New Biologics for the Modulation of Post-Infarct Remodeling: Matricryptins. J Am Coll Cardiol. 2015 Sep 22;66(12):1375-7. doi: 10.1016/j.jacc.2015.07.039. PubMed PMID: 26383725.

Jatho A, Hartmann S, Kittana N, Mügge F, Wuertz CM, Tiburcy M, Zimmermann WH, Katschinski DM, Lutz S. RhoA Ambivalently Controls Prominent Myofibroblast Characteritics by Involving Distinct Signaling Routes. PLoS One. 2015 Oct 8;10(10):e0137519. doi: 10.1371/journal.pone.0137519. eCollection 2015. PubMed PMID: 26448568.

Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, Stadler H, Kawabe H, Zimmermann WH, Nave KA, Schulz-Schaeffer W, Jahn O, Ehrenreich H. Widespread expression of erythropoietin receptor in brain and its induction by injury. Mol Med. 2015 Sep 1. doi: 10.2119/molmed.2015.00192. [Epub ahead of print] PubMed PMID: 26349059.

Sharma P, Abbasi C, Lazic S, Teng ACT, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann WH, Hamilton R, Sun Y, Liu PP, Keller G, Stagljar I, Scott IC, Kislinger T, Gramolini AO. Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015 6: 8391, doi: 10.1038/ncomms9391. PubMed PMID: 26403541.

Ongherth A, Pasch S, Wuertz CM, Nowak K, Kittana N, Weis CA, Jatho A, Vettel C, Tiburcy M, Toischer K, Hasenfuss G, Zimmermann WH, Wieland T, Lutz S. p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts. J Mol Cell Cardiol. 2015 Nov;88:39-54. doi: 10.1016/j.yjmcc.2015.09.009. Epub 2015 Sep 21. PubMed PMID: 26392029.

Hartmann S, Ridley AJ, Lutz S. The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease. Front Pharmacol. 2015 6:276, doi: 10.3389/fphar.2015.00276. PubMed PMID: 26635606.

Riegler J, Tiburcy M, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen VC, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH, Wu JC. Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model. Circ Res. 2015 117(8): 720-30, doi: 10.1161/CIRCRESAHA.115.306985. PubMed PMID: 26291556.

Yang T, Rubart M, Soonpaa MH, Didié M, Christalla P, Zimmermann WH, Field LJ. Cardiac engraftment of genetically-selected parthenogenetic stem cell-derived cardiomyocytes. PLoS One. 2015 Jun 25;10(6):e0131511. doi: 10.1371/journal.pone.0131511. eCollection 2015. PubMed PMID: 26110646.

Chang Liao ML, de Boer TP, Mutoh H, Raad N, Richter C, Wagner E, Downie BR, Unsöld B, Arooj I, Streckfuss-Bömeke K, Döker S, Luther S, Guan K, Wagner S, Lehnart SE, Maier LS, Stühmer W, Wettwer E, van Veen T, Morlock MM, Knöpfel T, Zimmermann WH. Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator. Circ Res. 2015 Aug 14;117(5):401-12. doi: 10.1161/CIRCRESAHA.117.306143. Epub 2015 Jun 15. PubMed PMID: 26078285.

Ritterhoff J, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RHA, Koch WJ, Katus HA, Most P. S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction. Mol Ther. 2015 23(8): 1320-30, doi: 10.1038/mt.2015.93. PubMed PMID: 26005840.

Godier-Furnémont AF, Tiburcy M, Wagner E, Dewenter M, Lämmle S, El-Armouche A, Lehnart SE, Vunjak-Novakovic G, Zimmermann WH. Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation. Biomaterials. 2015 Aug;60:82-91. doi: 10.1016/j.biomaterials.2015.03.055. Epub 2015 May 15. PubMed PMID: 25985155.

Unsöld B, Bremen E, Didié M, Hasenfuss G, Schäfer K. Differential PI3K signal transduction in obesity-associated cardiac hypertrophy and response to ischemia. Obesity. 2015 23(1): 90-9, doi: 10.1002/oby.20888. PubMed PMID: 25175008.

Unsöld B, Teucher N, Didié M, Sossalla S, Jacobshagen C, Seidler T, Schillinger W, Hasenfuß G. Negative hemodynamic effects of pantoprazole at high infusion rates in mice. Cardiovasc Ther. 2015 33(1): 20-6, doi: 10.1111/1755-5922.12102. PubMed PMID: 25529757.

Vogler M, Zieseniss A, Hesse AR, Levent E, Tiburcy M, Heinze E, Burzlaff N, Schley G, Eckardt KU, Willam C, Katschinski DM. Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflug Arch Eur J Phy. 2015 467(10): 2141-9, doi: 10.1007/s00424-014-1667-z. PMID: 25578858.


2014

Izarra A, Moscoso I, Levent E, Cañón S, Cerrada I, Díez-Juan A, Blanca V, Núñez-Gil IJ, Valiente I, Ruíz- Sauri A, Sepúlveda P, Tiburcy M, Zimmermann WH, Bernad A. miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial infarction. Stem Cell Reports. 2014 3(6): 1029-42, doi: 10.1016/j.stemcr.2014.10.010. PubMed PMID: 25465869.

Hesse AR, Levent E, Zieseniss A, Tiburcy M, Zimmermann WH, Katschinski DM. Lights on for HIF-1α: genetically enhanced mouse cardiomyocytes for heart tissue imaging. Cell Physiol Biochem. 2014 34(2): 455-62, doi: 10.1159/000363014. PubMed PMID: 25095893.

Tiburcy M, Meyer T, Soong PL, Zimmermann WH. Collagen-based engineered heart muscle. Methods Mol Biol. 2014;1181:167-76. doi: 10.1007/978-1-4939-1047-2_15. PubMed PMID: 25070336.

Zafiriou MP, Noack C, Unsöld B, Didie M, Pavlova E, Fischer HJ, Reichardt HM, Bergmann MW, El-Armouche A, Zimmermann WH, Zelarayan LC. Erythropoietin responsive cardiomyogenic cells contribute to heart repair post myocardial infarction. Stem Cells. 2014 Sep;32(9):2480-91. doi: 10.1002/stem.1741. PubMed PMID: 24806289.

Zimmermann WH. [Individualized stem cell therapy]. Herz. 2014 39(2): 201-5, doi: 10.1007/s00059-014- 4073-6. PubMed PMID: 24589843.

Vettel C, Lämmle S, Ewens S, Cervirgen C, Emons J, Ongherth A, Dewenter M, Lindner D, Westermann D, Nikolaev VO, Lutz S, Zimmermann WH, El-Armouche A. PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways. Am J Physiol-Heart C. 2014 306(8): H1246-52, doi: 10.1152/ajpheart.00852.2013. PubMed PMID: 24531807.

Didié M, Zimmermann WH. Ultrasound techniques for the detection of tumors and metastases in small animals. Methods Mol Biol. 2014 1070: 181-90, doi: 10.1007/978-1-4614-8244-4_13. PubMed PMID: 24092440.

Tiburcy M, Zimmermann WH. Modeling myocardial growth and hypertrophy in engineered heart muscle. Trends Cardiovas Med. 2014 24(1): 7-13, doi: 10.1016/j.tcm.2013.05.003. PubMed PMID: 23953977.

Kararigas G, Nguyen BT, Zelarayan LC, Hassenpflug M, Toischer K, Sanchez-Ruderisch H, Hasenfuss G, Bergmann MW, Jarry H, Regitz-Zagrosek V. Genetic background defines the regulation of postnatal cardiac growth by 17β-estradiol through a β-catenin mechanism. Endocrinology. 2014 155(7): 2667-76, doi: 10.1210/en.2013-2180. PubMed PMID: 24731099.

Bodmann EL, Rinne A, Brandt D, Lutz S, Wieland T, Grosse R, Bünemann M. <(2014) Dynamics of Gαq- protein-p63RhoGEF interaction and its regulation by RGS2. Biochem J. 2014 458(1): 131-40, doi: 10.1042/BJ20130782. PubMed PMID: 24299002.

Dewenter M, Vettel C, El-Armouche A. The Janus face of BNP therapy in chronic heart failure: beneficial effects unmasked by β blockers? Heart. 2014 100(11): 819-20, doi: 10.1136/heartjnl-2014-305503. PubMed PMID: 24667282.

Döker S, Dewenter M, El-Armouche A. [Tofacitinib]. Deut Med Wochenschr. 2014 139(19): 1003-8, doi: 10.1055/s-0034-1369986. PubMed PMID: 24782154.

Haj Slimane Z, Bedioune I, Lechêne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. Cardiovasc Res. 2014 102(1): 97-106, doi: 10.1093/cvr/cvu029. PubMed PMID: 24550350.

Neuber C, Müller OJ, Hansen FC, Eder A, Witten A, Rühle F, Stoll M, Katus HA, Eschenhagen T, El- Armouche A. Paradoxical effects on force generation after efficient β1-adrenoceptor knockdown in reconstituted heart tissue. J Pharmacol Exp Ther. 2014 349(1): 39-46, doi: 10.1124/jpet.113.210898. PubMed PMID: 24431469.

Neuber C, Uebeler J, Schulze T, Sotoud H, El-Armouche A, Eschenhagen T. Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes. Plos One. 2014 9(6): e98893, doi: 10.1371/journal.pone.0098893. PubMed PMID: 24892553.

Salamon J, Wicklein D, Didié M, Lange C, Schumacher U, Adam G, Peldschus K. Magnetic resonance imaging of single co-labeled mesenchymal stromal cells after intracardial injection in mice. Rofo-Fortschr Rontg. 2014 186(4): 367-76, doi: 10.1055/s-0034-1366097. PubMed PMID: 24683169.

Unsöld B, Kaul A, Sbroggiò M, Schubert C, Regitz-Zagrosek V, Brancaccio M, Damilano F, Hirsch E, Van Bilsen M, Munts C, Sipido K, Bito V, Detre E, Wagner NM, Schäfer K, Seidler T, Vogt J, Neef S, Bleckmann A, Maier LS, Balligand JL, Bouzin C, Ventura-Clapier R, Garnier A, Eschenhagen T, El-Armouche A, Knöll R, Tarone G, Hasenfuß G. Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. Cardiovasc Res. 2014 101(1): 97-107, doi: 10.1093/cvr/cvt235. PubMed PMID: 24130190.

Vettel C, Hottenrott MC, Spindler R, Benck U, Schnuelle P, Tsagogiorgas C, Krämer BK, Hoeger S, El-Armouche A, Wieland T, Yard BA. Dopamine and lipophilic derivates protect cardiomyocytes against cold preservation injury. J Pharmacol Exp Ther. 2014 348(1): 77-85, doi: 10.1124/jpet.113.207001. PubMed PMID: 24135075.

Zschüntzsch J, Jouvenal P, Zhang Y, Klinker F, Tiburcy M, Malzahn D, Liebetanz D, Brinkmeier H, Schmidt J. Human immunoglobulin G for experimental treatment of Duchenne muscular dystrophy. Clin Exp Immunol. 178 Suppl 1: 132-3, doi: 10.1111/cei.12541. PubMed PMID: 25546792.


2013

Zimmermann WH. Biomechanical regulation of in vitro cardiogenesis for tissue-engineered heart repair. Stem Cell Res Ther. 2013;4(6):137. Review. PubMed PMID: 24229468.

Ye L, Zimmermann WH, Garry DJ, Zhang J. Patching the heart: cardiac repair from within and outside. Circ Res. 2013 Sep 13;113(7):922-32. doi: 10.1161/CIRCRESAHA.113.300216. Review. PubMed PMID: 24030022.

Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ Res. 2013 Oct 25;113(10):1138-47. doi: 10.1161/CIRCRESAHA.113.302400. Epub 2013 Sep 4. PubMed PMID: 24006456.

Schwoerer AP, Neef S, Broichhausen I, Jacubeit J, Tiburcy M, Wagner M, Biermann D, Didié M, Vettel C, Maier LS, Zimmermann WH, Carrier L, Eschenhagen T, Volk T, El-Armouche A, Ehmke H. Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading. Pflugers Arch. 2013 Dec;465(12):1763-73. doi: 10.1007/s00424-013-1316-y. Epub 2013 Jul 11. PubMed PMID: 23842739.

Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26. PubMed PMID: 23810893.

Didié M, Biermann D, Buchert R, Hess A, Wittköpper K, Christalla P, Döker S, Jebran F, Schöndube F, Reichenspurner H, El-Armouche A, Zimmermann WH. Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants. Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H533-41. doi: 10.1152/ajpheart.00218.2013. Epub 2013 Jun 14. PubMed PMID: 23771692.

Didié M, Christalla P, Rubart M, Muppala V, Döker S, Unsöld B, El-Armouche A, Rau T, Eschenhagen T, Schwoerer AP, Ehmke H, Schumacher U, Fuchs S, Lange C, Becker A, Tao W, Scherschel JA, Soonpaa MH, Yang T, Lin Q, Zenke M, Han DW, Schöler HR, Rudolph C, Steinemann D, Schlegelberger B, Kattman S, Witty A, Keller G, Field LJ, Zimmermann WH. Parthenogenetic stem cells for tissue-engineered heart repair. J Clin Invest. 2013 Mar;123(3):1285-98. doi: 10.1172/JCI66854. Epub 2013 Feb 22. PubMed PMID: 23434590.

Renger A, Zafiriou MP, Noack C, Pavlova E, Becker A, Sharkova K, Bergmann MW, El-Armouche A, Zimmermann WH, Zelarayán LC. The four and a half LIM-domain 2 controls early cardiac cell commitment and expansion via regulating β-catenin-dependent transcription. Stem Cells. 2013 May;31(5):928-40. doi: 10.1002/stem.1332. PubMed PMID: 23341242.

Karikkineth BC, Zimmermann WH. Myocardial tissue engineering and heart muscle repair. Curr Pharm Biotechnol. 2013;14(1):4-11. Review. PubMed PMID: 23092254.

Streckfuss-Bömeke K, Wolf F, Azizian A, Stauske M, Tiburcy M, Wagner S, Hübscher D, Dressel R, Chen S, Jende J, Wulf G, Lorenz V, Schön MP, Maier LS, Zimmermann WH, Hasenfuss G, Guan K. Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts. Eur Heart J. 2013 Sep;34(33):2618-29. doi: 10.1093/eurheartj/ehs203. Epub 2012 Jul 12. PubMed PMID: 22798560.

Vogler M, Vogel S, Krull S, Farhat K, Leisering P, Lutz S, Wuertz CM, Katschinski DM, Zieseniss A. Hypoxia modulates fibroblastic architecture, adhesion and migration: a role for HIF-1α in cofilin regulation and cytoplasmic actin distribution. PLoS One. 2013 Jul 18;8(7):e69128. doi: 10.1371/journal.pone.0069128. Print 2013. PubMed PMID: 23874890.

Schroeter MR, Leifheit-Nestler M, Hubert A, Schumann B, Glückermann R, Eschholz N, Krüger N, Lutz S, Hasenfuss G, Konstantinides S, Schäfer K. Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains. Cardiovasc Res. 2013 Aug 1;99(3):555-65. doi: 10.1093/cvr/cvt126. Epub 2013 May 30. PubMed PMID: 23723060.

Hippe HJ, Lüdde M, Schnoes K, Novakovic A, Lutz S, Katus HA, Niroomand F, Nürnberg B, Frey N, Wieland T. Competition for Gβγ dimers mediates a specific cross-talk between stimulatory and inhibitory G protein α subunits of the adenylyl cyclase in cardiomyocytes. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386(6):459-69. doi: 10.1007/s00210-013-0876-x. Epub 2013 Apr 26. PubMed PMID: 23615874.

Lutz S, Mohl M, Rauch J, Weber P, Wieland T. RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase Iα.23195829.

Didié M, Zimmermann WH. Ultrasound techniques for the detection of tumors and metastases in small animals. Methods Mol Biol. 2014;1070:181-90. doi: 10.1007/978-1-4614-8244-4_13. PMID: 24092440