Publications

2011

Christalla P, Wittköpper K, El-Armouche A (2011) Febuxostat, ein neues Pharmakon zur Behandlung der Gicht Erhöhtes Herz-Kreislauf-Risiko bei Gichtpatienten? Der Kardiologe 5:45–50 [Link]

Grebe C, Klingebiel TM, Grau SP, Toischer K, Didié M, Jacobshagen C, Dullin C, Hasenfuss G, Seidler T (2011) Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo. Cardiovasc Res. [Epub ahead of print] [PubMed]

Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JD (2011) Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circ Res. 108(2):176-83. [PubMed]

Naito H, Tojo T, Kimura M, Dohi Y, Zimmermann WH, Eschenhagen T, Taniguchi S (2011) Engineering bioartificial tracheal tissue using hybrid fibroblast-mesenchymal stem cell cultures in collagen hydrogels. Interact Cardiovasc Thorac Surg. 12(2):156-61. [PubMed]

Sossalla S, Maurer U, Schotola H, Hartmann N, Didié M, Zimmermann WH, Jacobshagen C, Wagner S, Maier LS (2011) Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na(+) current. Basic Res Cardiol. 106(2):263-72. [PubMed]
Tsuji Y, Takanari H, Harada M, Hojo M, Inden Y, Murohara T, El-Armouche A, Dobrev D, Nattel S, Kodama I, Kamiya K (2011) Recurrent Ventricular Fibrillation Episodes Cause Ca2+-handling Protein Phosphorylation Abnormalities and Left Ventricular Function Deterioration: Insights from a New Experimental Model of Electrical Storm. Circulation [Epub ahead of print] [PubMed]

Zimmermann WH (2011) Embryonic and embryonic-like stem cells in heart muscle engineering. J Mol Cell Cardiol. 50(2):320-6. [PubMed]

 
2010

El-Armouche A, Schwoerer AP, Neuber C, Emmons J, Biermann D, Christalla T, Grundhoff A, Eschenhagen T, Zimmermann WH, Ehmke H (2010) Common microRNA signatures in cardiac hypertrophic and atrophic remodeling induced by changes in hemodynamic load. PLoS One. 5(12):e14263. [PubMed]

El-Armouche A, Wahab A, Wittköpper K, Schulze T, Böttcher F, Pohlmann L, King SB, Dumond JF, Gerloff C, Böger RH, Eschenhagen T, Carrier L, Donzelli S. (2010) The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes. Biochem Biophys Res Commun. 402:340-4. [PubMed]

Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, Bickeböller H, Maier LS, Schaper W, Schaper J, Kraft T, Tschöpe C, Linke WA, Chien KR (2010) A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. Circ Res. 106(4):695-704. [PubMed]

Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, Schwoerer AP, Lau D, Fu X, Klingel K, Sydow K, Didié M, Seniuk A, von Leitner EC, Szoecs K, Schrickel JW, Treede H, Wenzel U, Lewalter T, Nickenig G, Zimmermann WH, Meinertz T, Böger RH, Reichenspurner H, Freeman BA, Eschenhagen T, Ehmke H, Hazen SL, Willems S, Baldus S (2010) Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation. Nat Med. 16(4):470-4. [PubMed]

Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T, Wittköpper K, Renner A, Schmitto JD, Gummert J, El-Armouche A, Hasenfuss G, Maier LS (2010) Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium. Circ Res. 107: 1150-61. [PubMed]

Vantler M, Karikkineth BC, Naito H, Tiburcy M, Didié M, Nose M, Rosenkranz S, Zimmermann WH (2010) PDGF-BB protects cardiomyocytes from apoptosis and improves contractile function of engineered heart tissue. J Mol Cell Cardiol. 48(6):1316-23. [PubMed]

Wehrhan F, Nkenke E, Melnychenko I, Amann K, Schlegel KA, Goerlach C, Zimmermann WH, Schultze-Mosgau S (2010) Skin repair using a porcine collagen I/III membrane--vascularization and epithelization properties. Dermatol Surg. 36(6):919-30. [PubMed]
Wittköpper K, Fabritz L, Neef S, Ort KR, Grefe C, Unsöld B, Kirchhof P, Maier LS, Hasenfuss G, Dobrev D, Eschenhagen T, El-Armouche A. (2010) Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. J Clin Invest. 120(2):617-26. [PubMed]

Wuertz CM, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S. p63RhoGEF-a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. FASEB J. 24(12):4865-76. [PubMed]

 
2009
Deuse T, Peter C, Fedak PWM, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen T, Stein W, Wu JC, Robbins RC, Schrepfer S (2009) Hepatocyte Growth Factor or Vascular Endothelial Growth Factor Gene Transfer Maximizes Mesenchymal Stem Cell–Based Myocardial Salvage After Acute Myocardial Infarction. Circulation. 120:S247-54. [PubMed]
Elsner L, Flügge Perris F, Lozano J, Muppala V, Eiz-Vesper B, Demiroglu Sara Y, Malzahn D, Herrmann T, Brunner E, Bickeböller H, Multhoff G, Walter L, Dressel R (2009) The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells. J Cell Mol Med. (Epub ahead of print) [PubMed]
Heinrich A, Böer U, Tzvetkov M, Oetjen E, Knepel W (2009) Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator. Torc. Bioscience Rep. 29(2): 77-87. [PubMed]
Hentze H, Soong PL, Wang ST, Phillips BW, Putti TC, Dunn NR (2009) Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies. Stem Cell Res. 2(3):198-210. [PubMed]
Schinner S, Krätzner R, Baun D, Dickel C, Blume R, Oetjen E (2009) Inhibition of human insulin gene transcription by peroxisome proliferator-activated receptor gamma and thiazolidinedione oral antidiabetic drugs. Brit J Pharmacol (Epub). 157(5): 736-45. [PubMed]
Zimmermann WH, Cesnjevar R (2009) Cardiac tissue engineering: implications for pediatric heart surgery. Pediatr Cardiol. 30:716-23. [PubMed]
Zimmermann WH (2009) Remuscularizing Failing Hearts with Tissue Engineered Myocardium. Antioxid Redox Signal. 2009 Feb 9. [Epub ahead of print] [PubMed]
 
2008
Böer U, Cierny I, Krause D, Heinrich A, Lin H, Mayr G, Hiemke C, Knepel W (2008) Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice. Neuropsychopharmacol. 33(10): 2407-15. [PubMed]
El-Armouche A, Wittköpper K, Degenhardt F, Weinberger F, Didié M, Melnychenko I, Grimm M, Peeck M, Zimmermann WH, Unsöld B, Hasenfuss G, Dobrev D, Eschenhagen T (2008) Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy. Cardiovasc Res 80:396-406. [PubMed]
González M, Böer U, Dickel C, Quentin T, Cierny I, Oetjen E, Knepel W (2008) Loss of insulin-induced inhibition of glucagon gene transcription in hamster pancreatic islet alpha cells by long-term insulin exposure. Diabetologia. 51(11): 2012-21. [PubMed]
Jalil YA, Ritz V, Jakimenko A, Schmitz-Salue C, Siebert H, Awuah D, Kotthaus A, Kietzmann T, Ziemann C, Hirsch-Ernst KI (2008) Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6. Am J Physiol Cell Physiol. 294(2): C579-90. [PubMed]
Krätzner R, Fröhlich F, Lepler K, Schröder M, Röher K, Dickel C, Tzvetkov MV, Quentin T, Oetjen E, Knepel W (2008) A peroxisome proliferator-activated receptor gamma-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription. Mol Pharmacol.73(2): 509-17. [PubMed]
Krüger M, Sachse C, Zimmermann WH, Eschenhagen T, Klede S, Linke WA (2008) Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/ AKT pathway. Circ Res. 102(4):439-47. [PubMed]
Meineke C, Tzvetkov MV, Bokelmann K, Oetjen E, Hirsch-Ernst K, Kaiser R, Brockmöller J (2008) Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene. Pharmacogenet Genom. 18(3): 219-30. [PubMed]
Plaumann S, Blume R, Börchers S, Steinfelder HJ, Knepel W, Oetjen E (2008) Activation of the dual-leucine-zipper-bearing kinase and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin A. Mol Pharmacol. 73(3): 652-9. [PubMed]
Tiburcy M, Zimmermann WH (2008) Therapie des Diabetes mellitus Typ 2 und kardiovaskuläre Komplikationen: Was ist Evidenz-basiert? Der Kardiologe 2:417-429. [Link]
Wasmeier GH, Zimmermann WH, Schineis N, Melnychenko I, Voigt JU, Eschenhagen T, Flachskampf FA, Daniel WG, Nixdorff U (2008) Real-time myocardial contrast echocardiography for assessing perfusion and function in healthy and infarcted Wistar rats. Ultrasound Med Biol 34:47-55. [PubMed]
Werner JM, Steinfelder HJ (2008): A microscopic technique to study kinetics and concentration-response of drug-induced caspase-3 activation on a single cell level. J. Pharmacol. Toxicol. Methods. 57,131-7. [PubMed]
Wittköpper K, El-Armouche A, Eschenhagen T. Olanzapi (2008. Dtsch Med Wochenschr Sep;133(39): 1958-62. [PubMed]
Zimmermann WH (2008) Tissue engineering: polymers flex their muscles. Nat Mater 7:932-933. [PubMed]
Zimmermann WH (2008) Herzgewebe aus embryonalen Stammzellen. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 51:1021-5. [PubMed]
Zimmermann WH, Eschenhagen T (2008) Wie wichtig sind Medikamente? Herz heute 4:8-13.