Dr. Norman Liaw
Institute of Pharmacology and Toxicology,
University Medical Center Goettingen,
Robert-Koch-Str. 40, 37075 Goettingen
Tel: +49 (0) 551 39-5775
Fax: +49 (0) 551 39-5699
G'day visitors! I completed my PhD in 2013 under the supervision of A/Prof. Salvatore Pepe at the Murdoch Childrens Research Institute in Melbourne, Australia. In 2014, I commenced my postdoctoral training under the guidance of Prof. Dr. Wolfram-Hubertus Zimmermann. My move to Germany was a result of my interest in a unique model developed by Prof. Dr. Zimmermann termed engineered human myocardium (EHM) where the individual cellular composition of the human heart could be re-assembled into a fully defined, self-beating construct. My research utilises EHM to address the following topics:
Modelling IR injury in EHM using congenital heart disease stem cell-derived cardiomyocytes
Children born with congenital heart defects often require corrective surgery requiring the heart to be placed on temporary "bypass" using a heart-lung machine. The transition to and from this
machine is comparable to a small heart attack (or ischaemia-reperfusion injury, IR) since blood flow to the heart is briefly ceased and subsequently resumed. Whilst crucial to the success of
such surgeries, this act places significant stress on the already fragile neonatal heart. Therefore, utilising patient-derived stem cells within the EHM model, I am interested in modelling
the effect of IR on these EHM with a view to understand the functional and molecular mechanisms behind the additional stress and potentially improving post-operative outcomes.
Unravelling the complexities of the electrical conduction system in the developing myocardiumAnother facet of my research focuses on modelling and understanding the mechanisms involved in the developing human cardiac electrical conduction system. Since the fundamental principle of the heart is that it beats, how this is achieved in the early stages of embryonic development is somewhat not well understood. EHM utilsing stem cell-derived cardiomyocytes provides us with an opportunity to model these early stages and the application of electrical signals can be performed in vitro.
Available for research student supervision? Yes.
Mr. Branimir Berečić
Tel: +49 (0) 551 39-5777
Ms. Jeanette Hohneker
Mr. Paul Kunath
Mr. Yan Luo
Mr. Moritz Matthaei
Mr. Sebastian Nagel
Tel: +49 (0) 551 39-5777
Ms. Hannah Tschammer