Curriculum Vitae

Institute Director: Prof. Dr. med. Wolfram-Hubertus Zimmermann


Contact details

Education

2007 Habilitation and Venia Legendi, Pharmacology and Toxicology
2006 Board Certification in Pharmacology and Toxicology
1995-2000 Experimental Thesis in Pharmacology
University Medical Center Hamburg-Eppendorf, Hamburg, Germany
1998-2001 Postgraduate course in Molecular Biology
Center for Molecular Neurobiology and Institute of Pharmacology,
University Medical Center Hamburg-Eppendorf, Hamburg, Germany
1991-1998 M.D., University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Clinical electives at:
  • Duke University Medical School, Durham, USA
  • Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
  • Mount Auburn Hospital, Harvard Medical School, Boston, USA
  • Groote Schuur Hospital, University of Cape Town, South Africa

  • Academic Career

    2008 - Professor (W3) and Director
    Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany
    2004 - 2008 Junior Professor (Assistant Professor)
    Institute of Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    2003 - 2004 Lecturer and Staff Scientist
    Institute of Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    1999 - 2003 Resident
    Clinical Pharmacology, University Erlangen-Nuremberg

    Fellowships, Awards, and Honours (elected)

    2015 International Engagement Award, Basic Cardiovascular Science Council, AHA
    2014 Start-Up-Innovation Award by the Göttingen County
    2008 Fellow of the American Heart Association (AHA)
    2007 Dr. Martini Award by the Dr. Martini-Stiftung
    2007 Hengstberger-Stipend by the German Society of Cardiology
    2005 Fraenkel-Award by the German Society of Cardiology
    2004 Young Investigator Award (European Section) by the International Society for Heart Research
    2002 Minerva Short-Term Research Stipend at the Gepstein lab (Technion, Haifa, Isreal) by the Max-Planck Society
    2001 Research-Award for Development of Research Tools to Reduce Animal Experiments by the Federal Ministry of Food, Agriculture and Consumer Protection
    2001 Oskar-Lapp-Award by the German Society of Cardiology

    Professional Activities

    Editorial Boards
  • Circulation Research
  • Journal of Molecular and Cellular Cardiology
  • American Journal of Physiology
  • Basic Research in Cardiology
  • Regenerative Therapy
  • Memberships
  • German Society of Pharmacology and Toxicology (DGPT)
  • German Society of Cardiology (DGK)
  • European Society of Cardiology (ESC)
  • American Heart Association (AHA)
  • International Society of Heart Research (ISHR)
  • International Society for Stem Cell Research (ISSCR)
  • Safety Pharmacology Society (SPS)

  • Research Interests

    Cell-based heart repair, heart failure, tissue engineering, stem cell biology, physics in medicine, disease models, regenerative therapies, cell-cell/organ-organ cross talk, genome engineering

    Selected Publications

    Zimmermann WH, Fink C, Kralisch D, Remmers U, Weil J, Eschenhagen T. (2000) Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes. Biotechnol Bioeng 68:106-114. [PubMed]
    Zimmermann WH, Schneiderbanger K, Schubert P, Didie M, Munzel F, Heubach JF, Kostin S, Neuhuber WL, Eschenhagen T. (2002) Tissue engineering of a differentiated cardiac muscle construct. Circ Res 90:223-230. [PubMed]
    Zimmermann WH, Melnychenko I, Wasmeier G, Didie M, Naito H, Nixdorff U, Hess A, Budinsky L, Brune K, Michaelis B, Dhein S, Schwoerer A, Ehmke H, Eschenhagen T. (2006) Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. Nat Med 12:452-458. [PubMed]
    Tiburcy M, Didié M, Boy O, Christalla P, Doeker S, Naito H, Karikkineth BC, El-Armouche A, Grimm M, Nose M, Eschenhagen T, Zieseniss A, Katschinski D, Hamdani N, Linke WA, Yin X, Mayr M, Zimmermann WH. (2011) Terminal Differentiation, Advanced Organotypic Maturation, and Modeling of Hypertrophic Growth in Engineered Heart Tissue. Circ Res. 109:1105-1114. [PubMed]
    Soong PL, Tiburcy M, Zimmermann WH. (2012) Cardiac Differentiation of Human Embryonic Stem Cells and their Assembly into Engineered Heart Muscle. Curr Protoc Cell Biol 55:23.8.1-23.8.21. [PubMed]
    Didié M, Christalla P, Rubart M, Muppala V, Döker S, Unsöld B, El-Armouche A, Rau T, Eschenhagen T, Schwoerer AP, Ehmke H, Schumacher U, Fuchs S, Lange C, Becker A, Tao W, Scherschel JA, Soonpaa MH, Yang T, Lin Q, Zenke M, Han DW, Schöler HR, Rudolph C, Steinemann D, Schlegelberger B, Kattman S, Witty A, Keller G, Field LJ, Zimmermann WH. (2013) Parthenogenetic Stem Cells for Tissue Engineered Heart Repair. J Clin Invest 123:1285-1298. [PubMed]
    Godier-Furnémont AFG, Tiburcy M, Wagner E, Dewenter M, Lämmle S, El-Armouche A, Lehnart SE, Vunjak-Novakovic G, Zimmermann WH. (2015) Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation. Biomaterials 60:82-91 [PubMed]
    Chang Liao ML, de Boer TP, Mutoh H, Raad N, Richter C, Wagner E, Downie BR, Unsöld B, Arooj I, Streckfuss-Bömeke K, Döker S,Luther S, Guan K, Wagner S, Lehnart SE, Maier LS, Stühmer W, Wettwer E, van Veen T, Morlock MM, Knöpfel T, Zimmermann WH. Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator. Circ Res. 2015 Aug 14;117(5):401-12. [PubMed]
    Riegler J§, Tiburcy M§, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen V, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH*, Wu JC*. (2015) Human Engineered Heart Muscles Engraft and Survive Long-Term in a Rodent Myocardial Infarction Model. Circ Res 117:720-739. §first authors; *corresponding authors [PubMed]
    Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake LW, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH. (2017) Defined Engineered Human Myocardium with Advanced Maturation for Applications in Heart Failure Modelling and Repair. Circulation 135:1832-1847. [PubMed]