Curriculum Vitae

Group Leader: Prof. Dr. med. Niels Voigt


Contact details

    Prof. Dr. med. Niels Voigt
    Institute of Pharmacology and Toxicology,
    University Medical Center Goettingen,
    Robert-Koch-Str. 40, 37075 Goettingen
    Germany

    Tel: +49 (0) 551 39-65174
    Fax: +49 (0) 551 39-65169
    E-mail: niels.voigt[at]med.uni-goettingen.de

Research Interests

• Regulation of ion channels and calcium signaling in the normal and diseased heart
• Regulation of mitochondrial calcium-homeostasis in normal and diseased heart

Education and Scientific Career

2016 - Professor for Molecular Pharmacology
Institute of Pharmacology and Toxicology,
University Medical Center Göttingen, University of Göttingen, Germany
2012 - 2016 Postdoctoral Scientist
Institute of Pharmacology, University of Duisburg-Essen, Germany
2014 Facultas Docendi & Venia Legendi
(Senior Lecturer in Pharmacology and Toxicology)
2013 Board Certification in Pharmacology and Toxicology
2010 - 2012 Postdoctoral Scientist
Division of Experimental Cardiology, Medical Faculty Mannheim,
Heidelberg University, Germany
2008 - 2010 Postdoctoral Scientist
Department of Pharmacology and Toxicology, Medical Faculty,
Dresden University of Technology, Germany
2007 M.D. with merits (‘summa cum laude’) from the Medical Faculty "Carl Gustav Carus“, Dresden University of Technology, Germany
2007 Clinical examination and Graduation from Medical School
2000 - 2007 Medical School, Medical Faculty "Carl Gustav Carus“,
Dresden University of Technology, Germany
2003 - 2006 Doctoral thesis at the Department of Pharmacology and Toxicology, Dresden University of Technology, Germany

Experience at Research Institutes Abroad

2013 Laboratory of Dr. W. Jonathan Lederer
University of Maryland, Baltimore, USA
2008 Laboratory of Prof. Dr. David Eisner and Prof. Dr. Andrew Trafford
University of Manchester, Manchester, United Kingdom
2006 Laboratory of Prof. Dr. Stanley Nattel
Montreal Heart Institute, Montreal, Canada

Awards

2015 Teaching Award of the Medical Faculty of the University Duisburg-Essen 2015, Germany
2015 Oskar-Lapp-Award, German Cardiac Society, Germany
2013 Best of Basic Science Abstracts Award, American Heart Association Scientific Sessions 2013, Dallas, USA
2011 Poster Award, 35th Meeting of the European Working Group on Cardiac Cellular Electrophysiology, European Society of Cardiology, Oslo, Norway
2010 Highest Scoring Abstract Award from Germany, American Heart Association, Scientific Sessions 2010, Chicago, USA
2009 Woldemar Mobitz Award, German Cardiac Society, Germany
2009 Carl Gustav Carus Award for an outstanding dissertation, Medical Faculty, Dresden University of Technology, Germany
2004 Young Investigator Award 2004 (3rd Place), International Society for Heart Research (ISHR, European Section)

Editorial Boards

• Basic Research in Cardiology
• Archives of Medical Science
• Naunyn-Schmiedeberg’s Archives of Pharmacology
• Europace

Reviewer for Scientific Journals

Basic Research in Cardiology, Biochimica et Biophysica Acta - Molecular Cell Research, BioMed Central (BMC) Research Notes, Cellular Physiology and Biochemistry, Circulation Arrhythmia and Electrophysiology, Clincal Epidemiology, European Journal of Pharmacology, Fundamental and Clinical Pharmacology, Frontiers in Pharmacology, Heart, Hypertension, International Journal of Cardiology, Journal of Cardiovascular Disease Research, Journal of Cardiovascular Pharmacology, Journal of Molecular and Cellular Cardiology, International Journal of Cardiology, Naunyn Schmiedeberg’s Archive of Pharmacology, Physiological Reports

Professional Memberships

• American Heart Association (AHA)
• Cardiac Electrophysiology Society (CES)
• Working Group on Cardiac Cellular Electrophysiology (EWGCCE), European Society of Cardiology (ESC)
• German Cardiac Society (DGK)
• German Society of Experimental and Clinical Pharmacology and Toxicology (DGPT)
• Heart Rhythm Society (HRS)

Scientific Activities

since 2018 Chair of the Working Group on "Cellular Electrophysiology" (AG18) of the German Cardiac Society
since 2016 Ex-officio board member of Council of Stroke, European Society of Cardiology
since 2016 Vice-Chair of the Working Group on "Cellular Electrophysiology" (AG18) of the German Cardiac Society
since 2016 Nucleus member of “Scientists of Tomorrow”, European Society of Cardiology
2013-2017 Nucleus member of the Working Group on "Myocardial Function and Energetics" (AG13) of the German Cardiac Society

Funding

since 2018 Deutsche Forschungsgemeinschaft, Collaborative Research Center 1002 Project A13 (CRC1002 A13): “Role of chronic atrial stretch in the remodelling of Ca2+ handling in atrial myocytes from patients with heart failure"
since 2016 Deutsche Forschungsgemeinschaft, International Research Training Group Project 12 (DFG IRTG1816 RP12): “Remodeling of human atrial cardiomyocytes in response to in-vitro tachypacing"
since 2016 Deutsche Forschungsgemeinschaft (DFG VO 1568/3-1): “The role of atrial mitochondrial Ca2+-handling in arrhythmogenesis in patients with atrial fibrillation"
since 2016 Else Kröner-Fresenius-Stiftung (EKFS 2016_A20): “Cellular basis for triggers and perpetuators of postoperative atrial fibrillation.”

Selected Publications (five most important)

Voigt N, Heijman J, Wang Q, Chiang DY, Li N, Karck M, Wehrens XHT, Nattel S, Dobrev D. (2014) Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation, 129 (2): 145-56. [PubMed]
Voigt N, Heijman J, Trausch A, Mintert-Jancke E, Pott L, Ravens U, Dobrev D. (2013) Impaired Na+-dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation. J Mol Cell Cardiol, 61: 142-52. [PubMed]
Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Nattel S, Ravens U, Wehrens XHT, Dobrev D. (2012) Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation, 125 (17): 2059-70. (Highlighted in Circulation’s “Most Read Articles in Arrhythmia and Electrophysiology”, Circulation 2013, 127: e509-19) [PubMed]
Grandi E*, Pandit SV*, Voigt N*, Workman AJ, Dobrev D, Jalife J, Bers DM. (2011) Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res, 109 (9): 1055-66. *Equal contribuation. [PubMed]
Makary S*, Voigt N*, Maguy A*, Wakili R, Nishida K, Harada M, Dobrev D, Nattel S. (2011) Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling. Circ Res, 109 (9): 1031-43. *Equal contribuation. [PubMed]

Book Chapters

Dobrev D, Voigt N, Nattel S (2013) Cholinergic and constitutive regulation of atrial potassium channels. Cardiac Electrophysiology: From Cell to Bedside. Zipes D, Jalife J (eds), 6th edition, Elsevier, pp. 383-91. ISBN: 978-1-4556-2856-5
Nattel S, Voigt N, Dobrev D (2013) Molecular pathophysiology of atrial fibrillation. Cardiac Electrophysiology: From Cell to Bedside. Zipes D, Jalife J (eds), 6th edition, Elsevier, pp. 449-58. ISBN: 978-1-4556-2856-5