Curriculum Vitae

Group Leader: Dr. med. Malte Tiburcy


Contact details

    Dr. med. Malte Tiburcy
    Institute of Pharmacology and Toxicology,
    University Medical Center Goettingen,
    Robert-Koch-Str. 40, 37075 Goettingen
    Germany
    E-mail: m.tiburcy[at]med.uni-goettingen.de



Education and Scientific Career

2015 Board Certification in Pharmacology and Toxicology
2010 - Research Fellow, Institute of Pharmacology and Toxicology,
University Medical Center Goettingen
2008-2010 Resident, Department of Cardiology and Pneumology,
University Medical Center Goettingen
2007-2008 Postdoctoral Scientist, Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf
2007 M.D. from the Medical Faculty of the University of Greifswald
1999-2006 Studies of Medicine and German Medical Licensing Exam,
Universities of Greifswald, Hamburg, Toronto, London

Scientific Activities

2017 - Vice-Chair of Working Group on “Cardiac Regeneration” (AG31) of the German Society of Cardiology
2017 - Scientist in German Center for Cardiovascular Research (DZHK)
2016 - Co-Principal Investigator in Collaborative Research Center (CRC) 1002 “Modulatory Units in Heart Failure”
2016 - Nucleus Member of Working Group on “Cardiac Regeneration” (AG31) of the German Society of Cardiology
2013 - Young DZHK Scientist in German Center for Cardiovascular Research (DZHK)
2008 - Peer Review for Circulation, Cardiovascular Research, BMC Cell Biology, Transplantation, Scientific Reports

Fellowships and Awards (elected)

2009 Best Abstract Award, German Society for Stem Cell Research
2008 Travel stipend by the Glaxo-Smith-Kline foundation for AHA Scientific Sessions
2008 Doctoral thesis award by the Internal Medicine Society Mecklenburg-Vorpommern
2001-2002 Scholarship by the German Ministry of Health and Education (BMBF) for MD Thesis work

Professional Memberships

German Society of Pharmacology and Toxicology (DGPT)
German Society of Cardiology (DGK)
American Heart Association (AHA)
International Society for Stem Cell Research (ISSCR)

Research Interests

Cardiac tissue engineering, skeletal muscle engineering, muscle disease modeling, pluripotent stem cells (ESC, iPS) and muscle development, pharmacological substance screening, HMG-CoA reductase inhibitors and muscle

Selected Publications

Cyganek L, Tiburcy M, Sekeres K, Gerstenberg K, Bohnenberger H, Lenz C, Henze S, Stauske M, Salinas G, Zimmermann WH, Hasenfuss G, Guan K. (2018) Deep phenotyping of human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes. JCI Insight. [Accepted manuscript]
Long C, Li H, Tiburcy M, Rodriguez-Caycedo C, Kyrychenko V, Zhou H, Zhang Y, Min YL, Shelton JM, Mammen PPA, Liaw NY, Zimmermann WH, Bassel-Duby R, Schneider JW, Olson EN. (2018) Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing. Sci Adv, 31;4(1). [PubMed]
Borchert T, Hübscher D, Guessoum CI, Lam TD, Ghadri JR, Schellinger IN, Tiburcy M, Liaw NY, Li Y, Haas J, Sossalla S, Huber MA, Cyganek L, Jacobshagen C, Dressel R, Raaz U, Nikolaev VO, Guan K, Thiele H, Meder B, Wollnik B, Zimmermann WH, Lüscher TF, Hasenfuss G, Templin C, Streckfuss-Bömeke K. (2017) Catecholamine-dependent β-adrenergic signaling in a pluripotent stem cell model of Takotsubo cardiomyopathy. J Am Coll Cardiol, 22;70(8):975-991. [PubMed]
Kyrychenko V, Kyrychenko S, Tiburcy M, Shelton JM, Long C, Schneider JW, Zimmermann WH, Bassel-Duby R, Olson EN. (2017) Functional correction of dystrophin actinbinding domain mutations by genome editing. JCI Insight, 2(18). [PubMed]
Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake LW, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH. (2017) Defined Engineered Human Myocardium with Advanced Maturation for Applications in Heart Failure Modelling and Repair. Circulation 135:1832-1847. [PubMed]
Riegler J§, Tiburcy M§, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen V, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH*, Wu JC*. (2015) Human Engineered Heart Muscles Engraft and Survive Long-Term in a Rodent Myocardial Infarction Model. Circ Res 117:720-739. §first authors; *corresponding authors [PubMed]
Godier-Furnémont AFG§, Tiburcy M§, Wagner E, Dewenter M, Lämmle S, El-Armouche A, Lehnart SE, Vunjak-Novakovic G, Zimmermann WH. (2015) Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation. Biomaterials 60:82-91. §shared authorship. [PubMed]
Tiburcy M, Meyer T, Soong PL, Zimmermann WH. (2014) Collagen-based engineered heart muscle. Methods Mol Biol, 1181:167-176. [PubMed]
Tiburcy M, Zimmermann WH. (2014) Modeling myocardial growth and hypertrophy in engineered heart muscle. Trends Cardiovasc Med, 24(1):7-13. [PubMed]
Tiburcy M, Didié M, Boy O, Christalla P, Doeker S, Naito H, Karikkineth BC, El-Armouche A, Grimm M, Nose M, Eschenhagen T, Zieseniss A, Katschinski D, Hamdani N, Linke WA, Yin X, Mayr M, Zimmermann WH. (2011) Terminal Differentiation, Advanced Organotypic Maturation, and Modeling of Hypertrophic Growth in Engineered Heart Tissue. Circ Res. 109:1105-1114. [PubMed]

Patents

Meyer T, Tiburcy M, Zimmermann WH. Lochplatte. 2016060314484000DE (Priority date: 3.6.2016).
Tiburcy M, Hudson JE, Zimmermann W.-H., 2015. International PCT patent. "Method for producing Engineered Heart Muscle (EHM)". WO 2015/025030 A1.
Hudson JE, Tiburcy M, Zimmermann W.-H., 2015. International PCT patent. “A method to direct differentiation of pluripotent stem cells into functional heart muscle”. WO 2015/040142 Al.