Curriculum Vitae

Principal Investigator: Prof. Dr. rer. nat. Susanne Lutz


Contact details

    Prof. Dr. rer. nat. Susanne Lutz
    Institute of Pharmacology and Toxicology,
    University Medical Center Goettingen,
    Robert-Koch-Str. 40, 37075 Goettingen
    Germany

    Tel: +49 (0) 551 39-10665
    Fax: +49 (0) 551 39-5699
    E-mail: susanne.lutz[at]med.uni-goettingen.de

Academic Qualifications and Employment

2011 - Professor for Biochemical Pharmacology
Institute of Pharmacology and Toxicology, University Medical Center Goettingen
2010 - Head of the "GPCR-signalling Research Unit“
Institute of Pharmacology and Toxicology, University Medical Center Goettingen
2002 - 2010 Postdoctoral Fellow
Institute of Clinical and Experimental Pharmacology and Toxicology,
Medical Faculty Mannheim, University of Heidelberg
08/2006 - 10/2006 Visiting Researcher
Life Sciences Institute, University of Michigan, USA
1997 - 2002 Graduate research assistant
Department of Cardiology, Faculty of Medicine, University of Heidelberg, Dr. rer. nat. received.
1996 - 1997 Graduate research assistant
Institute of Human Genetics, Faculty of Medicine, University of Heidelberg
1995 Diploma in Biology
University of Konstanz, Germany

Society Memberships

Member of the German Society of Pharmacology
Member of the German Society of Cardiology
Member of the International Society for Heart Research

Reviewer

Cardiovascular Research
Journal of Molecular and Cellular Cardiology
Naunyn-Schmiedeberg’s Archives of Pharmacology

Selected Publications

Wuertz CM, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S. (2010) p63RhoGEF-a key mediator of angiotensin II- dependent signaling and processes in vascular smooth muscle cells. FASEB J.; 24(12): 4865-76. [PubMed]
Shankaranarayanan A, Boguth CA, Lutz S, Vettel C, Uhlemann F, Aittaleb M, Wieland T, Tesmer JJ. (2010) Galpha(q) allosterically activates and relieves autoinhibition of p63RhoGEF. Cell Signal.; 22(7): 1114-23. [PubMed]
Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ. (2007) Structure of Gaq-p63RhoGEF-RhoA complex reveals a pathway for activation of RhoA by GPCRs. Science; 318(5858): 1923-7. [PubMed]
Williams S, Lutz S, Charlie N, Vettel C, Ailion M, Coco C, Tesmer JJG, Jorgensen E, Wieland T, Miller K. (2007) Trio’s Rho-specific GEF domain is the missing Gaq effector in the C. elegans synaptic signalling network. Genes Dev.; 21(21): 2731-46. [PubMed]
Lutz S, Freichel-Blomquist A, Yang Y, Ruemenapp U, Jakobs KH, Schmidt M, Wieland T. (2005) The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. J Biol Chem.; 280(12): 11134-9. [PubMed]