Human stem cell models allow for the recapitulation of diseases in the dish. Novel mechanistic insight gained from human tissue engineered models may
identify unique therapeutic opportunities. The Tiburcy lab develops human disease models to understand the mechanisms underlying the progression of fatal diseases.
The focus is on degenerative heart and skeletal muscle diseases. In close collaboration with the
Stem Cell Unit, established jointly by the Institute of Pharmacology and Toxicology and the Clinic for Cardiology and Pneumology at the Heart Research Center
Göttingen, we have created a unique repository for comprehensive disease modelling. The overarching goal is to target the disease causing cell-specific mechanism
for pharmacologically induce repair and regeneration.
Godier-Furnémont AFG, Tiburcy M, Wagner E, Dewenter M, Lämmle S, El-Armouche A, Lehnart SE, Vunjak-Novakovic G,
Zimmermann WH. (2015) Physiologic force-frequency response in engineered heart muscle by electromechanical
stimulation. Biomaterials 60:82-91
Riegler J§, Tiburcy M§, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen V, Wang M,
Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH*, Wu JC*. (2015) Human Engineered Heart Muscles
Engraft and Survive Long-Term in a Rodent Myocardial Infarction Model. Circ Res 117:720-739. §first authors; *corresponding authors
Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J,
Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake LW, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G,
Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH. (2017) Defined Engineered
Human Myocardium with Advanced Maturation for Applications in Heart Failure Modelling and Repair. Circulation