Stem Cell Disease Modeling

Principal Investigator:

Dr. med. Malte Tiburcy

About Us

Human stem cell models allow for the recapitulation of diseases in the dish. Novel mechanistic insight gained from human tissue engineered models may identify unique therapeutic opportunities. The Tiburcy lab develops human disease models to understand the mechanisms underlying the progression of fatal diseases. The focus is on degenerative heart and skeletal muscle diseases. In close collaboration with the Stem Cell Unit, established jointly by the Institute of Pharmacology and Toxicology and the Clinic for Cardiology and Pneumology at the Heart Research Center Göttingen, we have created a unique repository for comprehensive disease modelling. The overarching goal is to target the disease causing cell-specific mechanism for pharmacologically induce repair and regeneration.


Selected Publications

  • Godier-Furnémont AFG, Tiburcy M, Wagner E, Dewenter M, Lämmle S, El-Armouche A, Lehnart SE, Vunjak-Novakovic G, Zimmermann WH. (2015) Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation. Biomaterials 60:82-91 [PubMed]

  • Riegler J§, Tiburcy M§, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen V, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH*, Wu JC*. (2015) Human Engineered Heart Muscles Engraft and Survive Long-Term in a Rodent Myocardial Infarction Model. Circ Res 117:720-739. §first authors; *corresponding authors [PubMed]

  • Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake LW, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH. (2017) Defined Engineered Human Myocardium with Advanced Maturation for Applications in Heart Failure Modelling and Repair. Circulation 135:1832-1847. [PubMed]
  • Contact details


      Dr. med. Malte Tiburcy

      Institute of Pharmacology and Toxicology,
      University Medical Center Goettingen,
      Robert-Koch-Str. 40, 37075 Goettingen, Germany
      Tel: +49 (0) 551 39-20729
      Fax: +49 (0) 551 39-5699

      E-mail Curriculum Vitae

    Staff


    Mr. Kashan David
    MD Student

    Main Building
    Tel: +49 (0) 551 39-5775


    Dr. rer. nat. Elif Levent
    Postdoctoral Scientist

    Main Building
    Tel: +49 (0) 551 39-10817


    Mr. Moritz Matthaei
    MD Student

    Main Building
    Tel: +49 (0) 551 39-5775


    Ms. Tabea Rekersbrink
    MD Student

    Main Building
    Tel: +49 (0) 551 39-5775


    Ms. Luisa Peter
    MD Student

    Main Building



    Ms. Susanne Schlick
    PhD Student

    Main Building
    Tel: +49 (0) 551 39-5775


    Ms. Mina Shahriyari
    PhD Student

    Main Building
    Tel: +49 (0) 551 39-5775