G Protein-Coupled Receptor Mediated Signaling

Principal Investigator:

Prof. Dr. rer. nat. Susanne Lutz

About Us

The research of our group focuses on G protein-dependent signaling in cardiac cells. We intend to identify signal cascades and mechanisms being involved in the pathology of heart diseases. This includes GPCR-driven signaling like the regulation of calcium handling in cardiac fibroblasts and its impact on protein secretion and thus in fibrotic processes. We are studying in addition the functions of guanine nucleotide exchange factors especially of the p63RhoGEF family, of RhoGTPases and their downstream effectors ROCK 1 and 2 in different cardiac cells with in vivo as well as in vitro models to identify their role in cardiac hypertrophy and fibrosis. Our methodological repertoire includes heart disease mouse models with subsequent analyses e.g. echocardiography, primary cell isolations from neonatal and adult animals, 3D culture models of homo- and heterogeneous cell populations, functional testing of 3D cultures including rheology and contraction measurements, viral gene delivery, life cell imaging, confocal imaging and several biochemical and molecular methods.


Selected Publications

  • Ongherth A, Pasch S, Wuertz CM, Nowak K, Kittana N, Weis CA, Jatho A, Vettel C, Tiburcy M, Toischer K, Hasenfuss G, Zimmermann WH, Wieland T, Lutz S. (2015) p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts. J Mol Cell Cardiol 88: 39-54. [PubMed]
  • Contact details


      Prof. Dr. rer. nat. Susanne Lutz

      Institute of Pharmacology and Toxicology,
      University Medical Center Goettingen,
      Robert-Koch-Str. 40, 37075 Goettingen, Germany
      Tel: +49 (0) 551 39-10665
      Fax: +49 (0) 551 39-5699

      E-mail Curriculum Vitae

    Staff


    Mr. Sebastian Pasch
    PhD Student

    Main Building
    Tel: +49 (0) 551 39-5306


    Ms. Jospephine Reichardt
    MD Student

    Main Building



    Mr. Abdul Rehman
    PhD Student

    Main Building
    Tel: +49 (0) 551 39-5777


    Ms. Gabriela Santos
    PhD Student

    Main Building
    Tel: +49 (0) 551 39-5306


    Ms. Kristin Xhaxho
    MD Student

    Main Building
    Tel: +49 (0) 551 39-5306


    Ms. Maren Wehner
    Secretary to Prof. Dr. Voigt and Prof. Dr. Lutz

    Main Building
    Tel: +49 (0) 551 39-65174